Antiparasitic Drug Joins Very Large COVID-19 Treatment Study – Precision Vaccinations
Led by the University of Oxford, the antiparasitic drug ivermectin is being investigated in the UK as part of PRINCIPE, the world’s largest clinical trial of possible COVID-19 treatments for recovery at home and in other non-hospital settings.
PRINCIPE is investigating treatments for people most at risk for serious illness from COVID-19 that can speed recovery, reduce the severity of symptoms and prevent hospitalizations. The study has so far recruited more than 5,000 volunteers from across the UK.
Ivermectin is the seventh treatment to be studied in the PRINCIPE trial and is currently being evaluated alongside the influenza antiviral drug favipiravir (Avigan).
Anyone who is eligible and showing symptoms of COVID-19 can participate in the trial from anywhere in the UK, either online, by phone or through their healthcare professional, the press release said. University published June 23, 2021.
The trial is supported by an extensive network of healthcare and care professionals in nursing homes, pharmacies, NHS 111 centers, hospitals and over 1,400 GP practices in England, Wales, UK Scotland and Northern Ireland. To learn more about how to participate in the study, visit www.principletrial.org.
With known antiviral properties, ivermectin has been shown to reduce the replication of SARS-CoV-2 in laboratory studies. Additionally, small pilot studies show that early administration of ivermectin may reduce viral load and duration of symptoms in some patients with mild COVID-19.
Even though ivermectin is used routinely in some countries to treat COVID-19, there is little evidence from large-scale randomized controlled trials to show that it can speed recovery from the disease or reduce hospitalizations. .
Ivermectin is widely used around the world to treat parasitic infections.
However, the US FDA has not approved ivermectin for use in the treatment or prevention of COVID-19 in humans. Ivermectin tablets are approved in specific doses for certain parasitic worms, and there are topical formulations for head lice and skin conditions like rosacea. Ivermectin is not an antiviral (a medicine to treat viruses).