What Does Science Say About Mixing Vaccines? -Health News, Firstpost
Studies have shown positive results with a mixture of AstraZeneca and Pfizer, but the question remains.
Editor’s Note: COVID-19 (novel coronavirus infection) Fact Checking is a series where we chat with doctors and ask burning questions about everything that concerns them. COVID-19 (novel coronavirus infection) – From treatment to vaccines and diagnosis.
If Shakespeare were alive he would say, “It doesn’t matter if you get it” because he’s rushing to vaccinate people.
Recently German Chancellor Angela Merkel Moderna vaccine As his second dose after receiving the AstraZeneca-Oxford vaccine.
The German Standing Committee on Immunization (STIKO) advice People “regardless of age” who received the AstraZeneca vaccine as their first vaccine and the mRNA vaccine as the second injection.
National Advisory Council on Immunization (NACI) of Canada Combination vaccine recommended “The mRNA vaccine is currently preferred as a second dose for people receiving the first dose of the AstraZeneca / Covishield vaccine,” he said.
The Spanish Bioethics Commission has asked people to receive the mRNA vaccine after the first dose of AstraZeneca. But they also said The second dose is importantEven if that means taking another dose of the AstraZeneca vaccine.
In the United States, the Food and Drug Administration (FDA) Combination vaccine not yet recommended..
Centers for Disease Control and Prevention (CDC) advice ” COVID-19 (novel coronavirus infection) Vaccines are not compatible.. However, under circumstances which must be taken into account, a person may be vaccinated with another vaccine.
So where does this lead to the mix of vaccines? Are there any negative side effects? Can I get two vaccines in India?
Let’s go check it out.
There are two types of adenovirus and mRNA vaccine COVID-19 (novel coronavirus infection) The plan currently in use.
The AstraZeneca and Johnson & Johnson vaccines are examples of adenovirus vaccines, while Pfizer and Moderna use mRNA. Sputnik V, also an adenovirus vaccine, consists of two different injections. Covacin, on the other hand, is created using inactivated or dead viruses.
These vaccines are completely different, “work differently, are made differently, and trigger an immune response,” said Dr Rohan Sequeira, internal medicine consultant at Jaslock Hospital and Research Center. ..
It is a divisive factor for health professionals. Some are all intended to mix vaccines, but others are still uncertain.
Dr Kate O’Brien, director of the vaccines unit at the World Health Organization (WHO), said: Associated Press, “Based on the basic principle of how vaccines work, we believe the mixed scheme works. “
Dr Sunil Jain, director of emergency medicine at Jaslok Hospital and Research Center, also COVID-19 (novel coronavirus infection) vaccine.
However, Daniel Altman, an immunologist at Imperial College London, has several different concerns. He stated Nature Repeated doses of virus vaccines may be less effective because the immune system elicits a response to the adenovirus. On the other hand, mRNA vaccination tends to have more serious side effects at higher doses. Coronavirus A pandemic is the first time that an mRNA vaccine has been approved, There is no way to know What happens when combined with an adenovirus vaccine?
Dr Tushar Tayal, Department of Internal Medicine, CK Birla Hospital, Gurgaon, does not recommend changing the vaccine because the Indian government recommends ending the vaccination course with the same vaccine.
Various studies on combination vaccines
Various studies have been conducted to understand the safety and effectiveness of combination vaccines and are at various stages of completion. Since these vaccines have been shown to be safe for humans and effective against SARS-CoV-2, the researchers took the following steps to ensure that they work well with each other and provide a stronger immune response. strong. I tried to find out if this would cause any.
Spanish Combivac S test: More than 600 people who received a single dose of AstraZeneca vaccine participated in the study. Two-thirds of the participants received Pfizer as a second dose. Preliminary results Showing that they have developed the neutralizing antibody SARS-CoV-2 more than 37 times, 4x more SARS-CoV-2 specific immune cells Only those who have only taken AstraZeneca once.
Com-COV research: 830 volunteers over 50 participated Research led by Oxford Find out if you want to mix your own vaccine with Pfizer Produces a better immune response. They tried two variations of the vaccination schedule: Pfizer followed by AstraZeneca and AstraZeneca followed by Pfizer. After 4 weeks, patients vaccinated with Pfizer at 4 week intervals after AstraZeneca showed a better immune response. They are also awaiting the results of a 12-week interval trial.
Sputnik V: Vaccine developed in Russia Sputnik V We have introduced a new version called Sputnik Light. It is supposed to act as a booster and can probably be combined with the AstraZeneca vaccine. Authorities say they will conduct research to determine the effectiveness of vaccines when combined.
These studies show, yes, you can mix and match your vaccine. And while some countries support it, India does not. But there is a tweet that it is possible.
What does India say?
The center would study the effects of mixed injections of two different vaccines. VK Paul, member of Niti Aayog Mentionned, “He [vaccine mixing] It is plausible. But we need to do more research … our experts are also continuing to study …Scientifically no problem.. “
There is some possibility Mixing vaccines can produce stronger immunity or more antibodies, Mentionned AIIMS Chief Dr. Landeep Grelia. “This has been seen in the past. Give one vaccine as a priming injection and another as a booster.
“We need more data… more vaccines will be available in the future… so we don’t know at this time which combination is best… but early research suggests that this might be an option. “He added.
Possible side effects of the combination vaccine
Mixture of vaccines Not a new technology.. The first combination vaccine was created in 1948 and was administered to treat individual diphtheria, tetanus and pertussis (DTP) and was first used in 1948 to immunize infants and children.
Even though the above studies show that it is safe to mix doses, there are always exceptions to the rules. What I learned from the AstraZeneca vaccine – Thrombocytopenia..
Jain mixes Pfizer and AstraZeneca, Mild to moderate side effects.. However, “these symptoms” were “short lived, within days, and there were no hospitalizations or other safety concerns,” he said.
Many countries have banned it since reports of blood clots associated with AstraZeneca. Those who received the first dose had no choice but to receive another vaccine.
“Mixing and matching allows us to complete the vaccination while ensuring safety. The evidence suggests it. The mixture “has a good safety profile”, “He added.
Sequeira also said he had never heard of reports of adverse effects on patients.
“It can actually produce a different type of immune response,” he says.
Maureen Ferrand, Associate Professor of Biology, Rochester Institute of Technology Mentionned By mixing the vaccine May help speed up global immunization End the pandemic faster. It can also “provide a more robust and long-lasting immune response and better protect people against new mutations.”
What Does Science Say About Mixing Vaccines? -Health News, Firstpost Source Link What Does Science Say About Mixing Vaccines? -Health News, Firstpost